Itinerary : Cartagena, Aruba, Willemstad (Curaçao), Colon - Panama, Cartagena



1 other departures
Serenade of the Seas
8 d
Inside Stateroom
Cartagena
3/22/2026
from
US$ 1,114
Other departures:
05 Apr 2026

South of Central America
The Republic of Panama is a country located at the southernmost tip of Central America, on the isthmus of the same name. Its territories border Costa Rica, as well as Colombia, to which it belonged before gaining independence. The country is bordered by both the Caribbean Sea and the Pacific Ocean. Panama was discovered by navigator Christopher Columbus on his fourth voyage. The first Spanish commercial settlement was established in 1503, and the isthmus was gradually colonized by conquistadors on behalf of the Spanish Empire. At this time, major roads were created to transport gold and silver from Peru, another Latin American country colonized by the Spanish. Initially a state of the Viceroyalty of Peru, Panama later became part of the Viceroyalty of New Granada, before joining Gran Colombia in 1821. A three-year war, supported by the Americans, brought independence to the country in 1903. Following this, in 1914 Panama granted the United States a perpetual canal agreement. Today, the country is Central America's most powerful economy, as well as a major tourist destination.
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Panama
Itinerary : Cartagena, Aruba, Willemstad (Curaçao), Colon - Panama, Cartagena



1 other departures
Serenade of the Seas
8 d
Inside Stateroom
Cartagena
3/22/2026
from
US$ 1,114
Other departures:
05 Apr 2026
Itinerary : Cartagena, Willemstad (Curaçao), Aruba, Colon - Panama, Cartagena



Serenade of the Seas
8 d
Suite
Cartagena
4/12/2026
from
US$ 4,182
Other ports of embarkation:
Colon - PanamaItinerary : Cartagena, Aruba, Kralendjik, Colon - Panama, Cartagena



Serenade of the Seas
8 d
Suite
Cartagena
3/29/2026
from
US$ 4,939
Other ports of embarkation:
Colon - PanamaItinerary : Tampa, Limon, Panama Canal, Grand Cayman, Tampa



1 other departures
Legend
9 d
Inside Stateroom
Tampa
1/16/2027
from
US$ 1,040
Other departures:
13 Mar 2027
Itinerary : Cartagena, Willemstad (Curaçao), Aruba, Colon - Panama



Serenade of the Seas
7 d
Balcony Stateroom
Cartagena
4/19/2026
from
US$ 758
Itinerary : Miami, Cartagena, Panama Canal, Panama City, Panama Canal, Panama City, Puerta Caldera, Puerto Quetzal, Acapulco, Puerto Vallarta, Cabo San Lucas, San Francisco, Astoria, Victoria, Seattle



Norwegian Encore
23 d
Inside Stateroom
Miami
4/11/2026
from
US$ 1,879
Itinerary : San Diego, Puerto Vallarta, Huatulco, Puerto Chiapas, Puerto Quetzal, Fuerte Amador, Panama canal (enter), Panama channel (Exit), Cartagena, Half Moon Cay, Miami



MS Zuiderdam
16 d
Inside Stateroom
San Diego
1/30/2027
from
US$ 2,692
Itinerary : Puerta Caldera, Quepos, Golfito, Coiba, Gulf of Chiriquí Marine Park (Panama), Isla de tortuga, Puerta Caldera



1 other departures
Star Clipper
8 d
Inside Stateroom
Puerta Caldera
1/2/2027
from
US$ 2,838
Other departures:
26 Dec 2026
Itinerary : Tampa, Cozumel, Costa Maya, Belize City, Roatan, Puerto Limon, Colon - Panama, Panama City



Oceania Insignia
11 d
Inside Stateroom
Tampa
3/25/2026
from
US$ 2,362
Itinerary : Miami, Cozumel, Costa Maya, Belize City, Roatan, Puerto Limon, Colon - Panama, Panama City



Oceania Insignia
11 d
Inside Stateroom
Miami
4/14/2026
from
US$ 3,418
Itinerary : Miami, Gustavia, Mayreau, Bonaire, Colon - Panama Canal



EUROPA
15 d
Suite
Miami
12/3/2028
from
US$ 6,486
Itinerary : Miami, Costa Maya, Harvest Caye, Roatan, Grand Cayman, Ocho Rios, Puerto Limon, Cartagena, Colon - Panama, Panama City



Seven Seas Grandeur
15 d
Suite
Miami
2/23/2027
from
US$ 10,197
Itinerary : Balboa, Pearl Islands, Isla Iguana, Coiba, Golfito, Quepos, Isla de tortuga, Puerta Caldera



Star Clipper
8 d
Inside Stateroom
Balboa
12/19/2026
from
US$ 2,916
Itinerary : Puerta Caldera, Isla de tortuga, Quepos, Golfito, Gulf of Chiriquí Marine Park (Panama), Isla Iguana, Pearl Islands, Balboa



Star Clipper
8 d
Inside Stateroom
Puerta Caldera
1/9/2027
from
US$ 2,916
Itinerary : Santiago, Coquimbo, Cristobal, Callao, Manta, Fuerte Amador, Panama Canal, Aruba, Fort Lauderdale



Queen Anne
20 d
Inside Stateroom
Santiago
2/28/2027
from
US$ 3,059
Panama City, the country's capital, is astonishingly modern. Like the Manhattan of Latin America, the city is divided into three distinct zones: the modern skyscraper district, Panama Antigua, and Casco Antiguo. Panama Antigua reveals to tourists the ruins of the original city, burnt to the ground and destroyed by the pirate Henry Morgan in 1621. Casco Antiguo is a colonial district, rich in history and heritage. Here you'll find the presidential palace and numerous churches. The entire area has been declared a UNESCO World Heritage Site.
Near the capital, you'll discover the famous Panama Canal, where you can still admire the deepening work. Even today, this impressive architectural work is considered one of the eight man-made wonders of the world. You can then head off into the rainforest, or discover Monkey Island, with its wildlife including monkeys, birds and iguanas.
On the Caribbean coast, off the coast of Panama, the Bacos del Toro archipelago reveals its natural charms. It comprises several islands, including Isla Colon, named after the country's discoverer. A small paradise, it offers surfing, scuba diving and dolphin watching off the coast. Also located in the Caribbean Sea, the San Blas archipelago boasts no fewer than 365 islands. Some of them are populated, offering you the chance to immerse yourself in the indigenous culture and kitesurf in clear, turquoise waters. Surf spots are also available on the Azuero peninsula, not far from the village of Las Tablos, famous for its traditional carnival. On the Pacific coast, the Panamanian Riviera has nothing to envy its French counterpart. Just an hour from the capital, you'll find luxury hotels, white sandy beaches and casinos for your entertainment. As you head further inland, don't miss Baguete, a picturesque town known for its coffee culture, or El Valle de Anton. Here, you'll discover the world's second-largest crater, as well as a rich and well-preserved biodiversity. Here, you can see orchids in the wild, as well as the famous golden frog.
Panama enjoys a tropical climate, with temperatures ranging from 24 to 29°C all year round. The country's tourist season extends from mid-December to around mid-April, during the dry season. The wetter rainy season runs from May to November. While the weather in Panama is less favorable during this period, it's also a very important time in terms of flora and fauna, as you can witness the migration of humpback whales and the laying of sea turtles.